Blockade of Interleukin 6 Signaling Induces Marked Neutropenia in Patients with Rheumatoid Arthritis

被引：35

作者：

Nakamura, Ichiro ^{[1
]}

Omata, Yasunori ^{[1
]}

Naito, Masashi ^{[1
]}

Ito, Katsumi ^{[1
]}

机构：

[1] Yugawara Kosei Nenkin Hosp, Dept Rheumatol, Kanagawa 2590314, Japan

来源：

JOURNAL OF RHEUMATOLOGY | 2009年 / 36卷 / 02期

关键词：

RECRUITMENT; TOCILIZUMAB; TRIAL; IL-6;

D O I：

10.3899/jrheum.080930

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

引用

页码：459 / 460

页数：2

共 5 条

[1]

INTERLEUKIN-6 SUPPRESSION OF NEUTROPHIL APOPTOSIS IS NEUTROPHIL CONCENTRATION-DEPENDENT [J].

BIFFL, WL ;

MOORE, EE ;

MOORE, FA ;

BARNETT, CC .

JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 58 (05) :582-584

[2]

IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation [J].

Hurst, SM ;

Wilkinson, TS ;

McLoughlin, RM ;

Jones, S ;

Horiuchi, S ;

Yamamoto, N ;

Rose-John, S ;

Fuller, GM ;

Topley, N ;

Jones, SA .

IMMUNITY, 2001, 14 (06) :705-714

[3]

Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia [J].

Jones, MR ;

Quinton, LJ ;

Simms, BT ;

Lupa, MM ;

Kogan, MS ;

Mizgerd, JP .

JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (03) :360-369

[4]

Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate [J].

Maini, R. N. ;

Taylor, P. C. ;

Szechinski, J. ;

Pavelka, K. ;

Broell, J. ;

Balint, G. ;

Emery, P. ;

Raemen, F. ;

Petersen, J. ;

Smolen, J. ;

Thomson, D. ;

Kishimoto, T. .

ARTHRITIS AND RHEUMATISM, 2006, 54 (09) :2817-2829

[5]

Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab [J].

Nishimoto, Norihiro ;

Hashimoto, Jun ;

Miyasaka, Nobuyuki ;

Yamamoto, Kazuhiko ;

Kawai, Shinichi ;

Takeuchi, Tsutomu ;

Murata, Norikazu ;

van der Heijde, Desiree ;

Kishimoto, Tadamitsu .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (09) :1162-1167

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