Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion

被引：46

作者：

Chang, ML

Yang, J

Kem, S

Klaidman, L

Sugawara, T

Chan, PH

Adams, JD

机构：

[1] Univ So Calif, Dept Mol Pharmacol & Toxicol, Sch Pharm, Los Angeles, CA 90089 USA

[2] Stanford Univ, Sch Med, Dept Neurosurg, Neurosurg Labs, Palo Alto, CA 94304 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 322卷 / 03期

关键词：

stroke; middle cerebral artery occlusion model; nicotinamide; ketamine; DNA fragmentation; infarction;

D O I：

10.1016/S0304-3940(01)02520-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The possible ability of nicotinamide and ketamine to decrease infarction volume and DNA fragmentation was investigated in a middle cerebral artery occlusion rat model. DNA fragmentation was measured with an enzyme linked immunoassay. Control infarct volume was 223.8 +/- 10.6 mm(3). Ketamine alone did not alter infarct volume, 233.2 +/- 61.8 mm(3). Nicotinamide alone did not alter infarct volume, 235.2 +/- 62.8 mm(3). The combination of ketamine and nicotinamide decreased infarct volume to 83.8 +/- 35.2 mm(3). Ketamine produced hypothermia. Nicotinamide and ketamine decreased brain swelling and DNA fragmentation in the cerebral cortex, striatum and hippocampus in rats perfused for 6 or 24 h. Ketamine may synergize the actions of nicotinamide and partially prevent brain damage from ischemia and reperfusion. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：137 / 140

页数：4

共 18 条

[1]

Adams J, 2000, OXIDAT STRESS DIS, P55

[2]

Adams James D., 1999, Society for Neuroscience Abstracts, V25, P1846

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