Remote controlled capsules in human drug absorption (HDA) studies

被引：22

作者：

Wilding, IR ^{[1
]}

Prior, DV ^{[1
]}

机构：

[1] Pharmaceut Profiles Ltd, Nottingham, England

来源：

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS | 2003年 / 20卷 / 06期

关键词：

oral absorption; gastrointestinal tract; site-specific; gamma scintigraphy; intelligent capsules;

D O I：

10.1615/CritRevTherDrugCarrierSyst.v20.i6.10

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The biopharmaceutical complexity of today's new drug candidates provides significant challenges for pharmaceutical scientists in terms of both candidate selection and optimizing subsequent development strategy. In addition, life cycle management of marketed drugs has become an important income stream for pharmaceutical companies, but the selection of least risk/highest benefit strategies is far from simple. The proactive adoption of human drug absorption (HDA) studies using remote controlled capsules offers the pharmaceutical scientist significant guidance for planning a route through the maze of product development. This review examines the position of HDA studies in drug development, using a variety of case histories and an insightful update on remote controlled capsules to achieve site-specific delivery.

引用

页码：405 / 431

页数：27

共 39 条

[1] Drug exsorption from blood into the gastrointestinal tract [J].