Hepatitis C virus and hepatocellular carcinoma

被引:51
作者
Colombo, M
机构
[1] Univ Milan, IRCCS Maggiore Hosp, FIRC Univ Unit Liver Canc, I-20122 Milan, Italy
[2] Univ Milan, Angela Maria & Antonio Migliavacca Ctr Liver Dis, Div Internal Med, I-20122 Milan, Italy
关键词
hepatitis C virus; hepatocellular carcinoma; cirrhosis;
D O I
10.1055/s-2007-1007116
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatitis C virus (HCV) is pathogenetically involved in many cases of hepatocellular carcinoma (HCC) worldwide. HCV-related HCC is on the rise in many developed countries as a consequence of past infections with HCV. The time lag between HCV infection and cancer development is several decades. HCV-related tumors arise in older patients, are almost invariably associated with cirrhosis, and often have a less aggressive course than HCC related to other etiologic factors. In most patients, HCC grows as a single hepatic node for years before generating satellite or distant tumor nodes. However there are tumors that originate as multifocal disease. Tumor progression and hepatic failure are the leading causes of death in most patients. HCV has been almost invariably detected in tumor tissue of anti-HCV patients with HCC, but it is not clear whether the virus promotes cancer through chronic hepatocellular inflammation, which is per se an important risk factor for HCC, or has a direct role in liver carcinogenesis. No reverse transcriptase activity has been found in infected livers, but there are data suggesting that HCV has oncogenic properties, because its interacts with cellular genes regulating cell growth and differentiation.
引用
收藏
页码:263 / 269
页数:7
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