Myelodysplastic syndrome following successful therapy of acute promyelocytic leukemia

被引：22

作者：

Bseiso, AW ^{[1
]}

Kantarjian, H ^{[1
]}

Estey, E ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT HEMATOL,HOUSTON,TX 77030

来源：

LEUKEMIA | 1997年 / 11卷 / 01期

关键词：

secondary myelodysplastic syndrome; acute promyelocytic leukemia;

D O I：

10.1038/sj.leu.2400539

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We describe a patient with acute promyelocytic leukemia (APL) who was successfully induced into remission with all-trans retinoic acid (ATRA) and idarubicin, but developed myelodysplastic syndrome (MDS) with monosomy 7 shortly after conclusion of maintenance therapy with idarubicin alternating with 6-mercaptopurine, vincristine, methotrexate and prednisone. Patients on combination regimens of ATRA or other retinoids and chemotherapy, which are being increasingly used in recent years, should be closely monitored for the development of potentially new complications including MDS.

引用

页码：168 / 169

页数：2

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