Endometrial carcinoma associated with hyperplasia

The aim of this study was to clarify the relationship of endometrial hyperplasia to endometrial carcinoma From 1979 through 1990, 115 cases of stage I-IV endometrial carcinomas treated initially by hysterectomy a ere reviewed histologically. Forty-two of 115 (36.5%) patients had hyperplasia in the endometrium adjacent to the carcinoma, Women with both endometrial carcinoma and hyperplasia were significantly younger than those with carcinoma without hyperplasia (P < 0.05). In a comparison of patients with carcinoma without hyperplasia, those with hyperplasia were better differentiated (P = 0.0072), and lacked deep myometrial invasion (P < 0.0001), cervical involvement (P = 0.0192), lymph-vascular space invasion (P = 0.0102), and para-aortic lymph node metastases (P = 0.0334). The presence of hyperplasia was also significantly correlated with the presence of endometrial metaplasia (P = 0.0001). The estimated 5-year survival rates for patients with carcinoma with hyperplasia and those with carcinoma without hyperplasia were 96.55 and 73.33%, respectively (P = 0.0016). In endometrial carcinomas, the presence of endometrial hyperplasia may demonstrate a more favorable prognosis. (C) 1996 Academic Press, Inc.