Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role

被引：665

作者：

Crider, Krista S. ^{[1
]}

Yang, Thomas P. ^{[2
]}

Berry, Robert J. ^{[1
]}

Bailey, Lynn B. ^{[3
]}

机构：

[1] Natl Ctr Birth Defects & Dev Disabil, Div Birth Defects & Dev Disabil, Atlanta, GA USA

[2] Univ Florida, Coll Med, Dept Biochem & Mol Biol, Ctr Epigenet,Div Pediat Genet, Gainesville, FL 32610 USA

[3] Univ Georgia, Dept Food & Nutr, Athens, GA 30602 USA

来源：

ADVANCES IN NUTRITION | 2012年 / 3卷 / 01期

关键词：

CPG-ISLAND METHYLATION; FOLIC-ACID SUPPLEMENTATION; GERM-CELL DEVELOPMENT; GLOBAL DNA; METHYLENETETRAHYDROFOLATE REDUCTASE; S-ADENOSYLHOMOCYSTEINE; PLASMA HOMOCYSTEINE; PRENATAL EXPOSURE; DEVELOPMENTAL ORIGINS; MEGALOBLASTIC-ANEMIA;

D O I：

10.3945/an.111.000992

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

DNA methylation is an epigenetic modification critical to normal genome regulation and development. The vitamin folate is a key source of the one carbon group used to methylate DNA. Because normal mammalian development is dependent on DNA methylation, there is enormous interest in assessing the potential for changes in folate intake to modulate DNA methylation both as a biomarker for folate status and as a mechanistic link to developmental disorders and chronic diseases including cancer. This review highlights the role of DNA methylation in normal genome function, how it can be altered, and the evidence of the role of folate/folic acid in these processes. Adv. Nutr. 3: 21-38, 2012.

引用

页码：21 / 38

页数：18

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