Design, synthesis, and antitumor activity of bicyclic and isomeric analogues of illudin M

被引：35

作者：

Kinder, FR

Wang, RM

Bauta, WE

Bair, KW

机构：

[1] Oncology Research Program, Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, East Hanover

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 09期

关键词：

D O I：

10.1016/0960-894X(96)00167-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel bicyclic and isomeric analogues of the cytotoxic sesquiterpine illudin M were prepared using 1,3-dipolar cycloaddition reactions. Nearly every analogue investigated demonstrated low mu M IC50 values when tested in a panel of four human tumor cell lines. (C) 1996 Elsevier Science Ltd.

引用

页码：1029 / 1034

页数：6

共 13 条

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