Computer analysis of regulatory signals in bacterial genomes. Fnr binding sites

被引：4

作者：

Gerasimova, AV ^{[1
]}

Rodionov, DA ^{[1
]}

Mironov, AA ^{[1
]}

Gelfand, AS ^{[1
]}

机构：

[1] State Res Ctr Biotechnol GosNIIGenet, Moscow 113545, Russia

来源：

MOLECULAR BIOLOGY | 2001年 / 35卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

Fnr; computer analysis; aerobic/anaerobic regulation; Escherichia coli;

D O I：

10.1023/A:1013286202014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Comparative approach to computer analysis of regulatory signals allows one to predict new signals in bacterial genomes with high accuracy. A prediction is reliable whenever candidate signals are consistently observed in several related genomes. We applied comparative approach to the analysis of the Fnr regulon of gamma-proteobacteria. Responding to changes in the aerobic/anaerobic state of the medium, the transcriptional factor Fnr regulates expression of many genes. We predicted Fnr binding sites in 12 genes regulated by Fnr, and identified 17 new operons as potential members of the Fnr regulon of Escherichia coli. In addition, we described the Fnr regulon of other gamma-proteobacteria.

引用

页码：853 / 861

页数：9

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