Apoptosis: an innate immune response to virus infection

被引：359

作者：

Everett, H ^{[1
]}

McFadden, G

机构：

[1] Univ Western Ontario, John P Robarts Res Inst, London, ON N6G 2V4, Canada

[2] Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6G 2V4, Canada

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0966-842X(99)01487-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viruses can induce apoptosis of infected cells either directly, to assist virus dissemination, or by inadvertently triggering cellular sensors that initiate cell death. Cellular checkpoints that can function as 'alarm bells' to transmit pro-apoptotic signals in response to virus infections include death receptors, protein kinase R, mitochondrial membrane potential, p53 and the endoplasmic reticulum.

引用

页码：160 / 165

页数：6

共 57 条

[1] Identification of a cellular receptor for subgroup E avian leukosis virus [J].

Adkins, HB ;

Brojatsch, J ;

Naughton, J ;

Rolls, MM ;

Pesola, JM ;

Young, JAT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) :11617-11622

[2]

Ahsan N, 1998, SEMIN NEPHROL, V18, P422

[3]

Akaike T, 1998, P SOC EXP BIOL MED, V217, P64

[4] CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis [J].

Algeciras, A ;

Dockrell, DH ;

Lynch, DH ;

Paya, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (05) :711-720

[5] Death receptors: Signaling and modulation [J].

Ashkenazi, A ;

Dixit, VM .

SCIENCE, 1998, 281 (5381) :1305-1308

[6] Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling [J].

Balachandran, S ;

Kim, CN ;

Yeh, WC ;

Mak, TW ;

Bhalla, K ;

Barber, GN .

EMBO JOURNAL, 1998, 17 (23) :6888-6902

[7] Apoptosis regulators from DNA viruses [J].

Barry, M ;

McFadden, G .

CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (04) :422-430

[8] The myxoma virus M-T4 gene encodes a novel RDEL-containing protein that is retained within the endoplasmic reticulum and is important for the productive infection of lymphocytes [J].

Barry, M ;

Hnatiuk, S ;

Mossman, K ;

Lee, SF ;

Boshkov, L ;

McFadden, G .

VIROLOGY, 1997, 239 (02) :360-377

[9] CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4+ T cells [J].

Berndt, C ;

Möpps, B ;

Angermüller, S ;

Gierschik, P ;

Krammer, PH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12556-12561

[10] CAR1, a TNFR-related protein, is a cellular receptor for cytopathic avian leukosis sarcoma viruses and mediates apoptosis [J].

Brojatsch, J ;

Naughton, J ;

Rolls, MM ;

Zingler, K ;

Young, JAT .

CELL, 1996, 87 (05) :845-855

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