High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women

被引：249

作者：

Hedstrom, Anna K. ^{[1
]}

Olsson, Tomas ^{[2
,3
]}

Alfredsson, Lars ^{[1
]}

机构：

[1] Karolinska Inst, Inst Environm Med, S-14153 Stockholm, Sweden

[2] Karolinska Univ Hosp, Karolinska Inst, Neuroimmunol Unit, Dept Clin Neurosci, Solna, Sweden

[3] Karolinska Univ Hosp, Karolinska Inst, Neuroimmunol Unit, Ctr Mol Med, Solna, Sweden

来源：

MULTIPLE SCLEROSIS JOURNAL | 2012年 / 18卷 / 09期

关键词：

OBESITY; MACROPHAGES; CANADA;

D O I：

10.1177/1352458512436596

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a Swedish population-based case-control study (1571 cases, 3371 controls), subjects with different body mass indices (BMIs) were compared regarding multiple sclerosis (MS) risk, by calculating odds ratios (OR) with 95% confidence intervals (95% CI). Subjects whose BMI exceeded 27 kg/m(2) at age 20 had a two-fold increased risk of developing MS compared with normal weight subjects. Speculatively, the obesity epidemic may explain part of the increasing MS incidence as recorded in some countries. Measures taken against adolescent obesity may thus be a preventive strategy against MS.

引用

页码：1334 / 1336

页数：3

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