Angiotensin II type 1 receptor antagonists inhibit cell proliferation and angiogenesis in breast cancer

被引：120

作者：

Chen, Xuesong ^{[1
]}

Meng, Qingwei ^{[1
]}

Zhao, Yanbin ^{[1
]}

Liu, Meiyan ^{[1
]}

Li, Dandan ^{[1
]}

Yang, Yanmei ^{[2
]}

Sun, Lichun ^{[1
]}

Sui, Guangjie ^{[1
]}

Cai, Li ^{[1
]}

Dong, Xiaoqun ^{[3
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 3, Dept Internal Med Oncol, Harbin 150040, Heilongjiang Pr, Peoples R China

[2] Harbin Med Univ, Canc Res Inst, Harbin 150040, Heilongjiang Pr, Peoples R China

[3] Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA

来源：

CANCER LETTERS | 2013年 / 328卷 / 02期

关键词：

Angiotensin (AT) II; Angiotensin II type 1 receptor (AT1R); Vascular endothelial growth factor (VEGF) A; Breast cancer; CARCINOMA CELLS; BLADDER-CANCER; GROWTH-FACTOR; AT2; RECEPTOR; MOUSE MODEL; EXPRESSION; PROSTATE; HYPERPLASIA; ACTIVATION; BLOCKERS;

D O I：

10.1016/j.canlet.2012.10.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Angiotensin II type 1 receptor (AT1R) promotes tumor invasion, migration, metastasis and angiogenesis. We explored the potential antitumor effects of AT1R antagonists in breast cancer. We found that angiotensin II promoted cell proliferation and upregulated the expression of vascular endothelial growth factor A (VEGF-A) in MCF-7 cells. Losartan downregulated the expression of VEGF-A in MCF-7 cells treated with angiotensin II. Candesartan downregulated the expression of VEGF-A in mice bearing MCF-7 xenografts and inhibited tumor growth and angiogenesis. AT1R and VEGF-A expression correlated with increased microvascular density in 102 breast cancer patients. Our data suggest that AT1R antagonists might be useful to suppress breast cancer by inhibiting the angiotensin II. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：318 / 324

页数：7

共 31 条

[1]

Increasing Incidence of Pregnancy-Associated Breast Cancer in Sweden [J].