FGF-2 Low Molecular Weight Selectively Promotes Neuritogenesis of Motor Neurons In Vitro

被引：24

作者：

Allodi, Ilary ^{[1
,2
,3
]}

Casals-Diaz, Laura ^{[1
,2
,3
]}

Santos-Nogueira, Eva ^{[1
,2
,3
]}

Gonzalez-Perez, Francisco ^{[1
,2
,3
]}

Navarro, Xavier ^{[1
,2
,3
]}

Udina, Esther ^{[1
,2
,3
,4
]}

机构：

[1] Univ Autonoma Barcelona, Inst Neurosci, Grp Neuroplast & Regenerat, Bellaterra 08193, Spain

[2] Univ Autonoma Barcelona, Dept Cell Biol Physiol & Immunol, Bellaterra 08193, Spain

[3] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Bellaterra, Spain

[4] Univ Autonoma Barcelona, Fac Med, Bellaterra 08193, Spain

来源：

MOLECULAR NEUROBIOLOGY | 2013年 / 47卷 / 02期

关键词：

Axonal regeneration; Motor neuron; Sensory neuron; In vitro cultures; FGF-2; Cell adhesion molecules; FGFR-1; PERIPHERAL-NERVE REGENERATION; FIBROBLAST-GROWTH-FACTOR; CELL-ADHESION MOLECULE; ADULT SENSORY NEURONS; NEUROTROPHIC FACTOR; NEURITE OUTGROWTH; SCHWANN-CELLS; SCIATIC-NERVE; SKELETAL-MUSCLE; EXPRESSION;

D O I：

10.1007/s12035-012-8389-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization.

引用

页码：770 / 781

页数：12

共 38 条

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