Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population

被引：30

作者：

Douroudis, K. ^{[1
]}

Prans, E. ^{[1
]}

Haller, K. ^{[1
]}

Nemvalts, V. ^{[2
]}

Rajasalu, T. ^{[3
]}

Tillmann, V. ^{[4
]}

Kisand, K. ^{[1
]}

Uibo, R. ^{[1
]}

机构：

[1] Univ Tartu, IGMP, Dept Immunol, Ctr Mol & Clin Med, EE-51014 Tartu, Estonia

[2] Kuressaare Hosp, Dept Internal Med, Kuressaare, Estonia

[3] Univ Tartu, Dept Internal Med, EE-51014 Tartu, Estonia

[4] Univ Tartu, Dept Paediat, EE-51014 Tartu, Estonia

来源：

TISSUE ANTIGENS | 2008年 / 72卷 / 05期

关键词：

protein tyrosine phosphatase non-receptor type 22; single nucleotide polymorphism; type; 1; diabetes; 2;

D O I：

10.1111/j.1399-0039.2008.01115.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is considered an important regulator of T-cell activation. Polymorphisms within the PTPN22 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. To evaluate the impact of a functional variation in the PTPN22 gene in type 1 (T1D) and type 2 diabetes (T2D), the PTPN22 C1858T single nucleotide polymorphism (SNP) was studied in the population of Estonian origin, including 170 T1D patients, 244 T2D patients and 230 controls. Using two methods for PTPN22 C1858T detection in parallel, we found that not only T1D but also T2D is associated with the PTPN22 1858T allele. The role of PTPN22 gene in the pathogenesis of T2D is yet unclear and needs further investigation.

引用

页码：425 / 430

页数：6

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