Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

被引:442
作者
Cullinan, SB
Diehl, JA
机构
[1] Univ Penn, Ctr Canc, Leonard & Madlyn Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[2] Univ Penn, Ctr Canc, Dept Canc Biol, Philadelphia, PA 19104 USA
关键词
PERK; Nrf2; ER stress; oxidative stress;
D O I
10.1016/j.biocel.2005.09.018
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the broadest sense, cellular stress describes conditions wherein cells encounter and react to a 'non-normal' state. Perturbations may originate through both extracellular and intracellular means. Whereas transient levels of stress are expected to occur on a regular basis, a series of checks and balances ensures that cells are well equipped to maintain a homeostatic state. In the case of supra-physiological stress signaling, cellular challenges are more severe, and programmed cell death may be the best option for the organism. The ability of a cell, and by extension, an organism, to adequately manage cellular stress is fundamental-a question of life or death. The endoplasmic reticulum (ER) is exquisitely poised to sense and respond to cellular stresses including those that result from metabolic and/or protein folding imbalances. In response to stress originating from within the ER. the PERK and Ire I protein kinases, along with other proximal signaling molecules, initiate a program of transcriptional and translational regulation termed the unfolded protein response. A consequence of ER stress is the accumulation of reactive oxygen species that promotes a state of oxidative stress. PERK signaling, via activation of the Nrf2 and ATF4 transcription factors, coordinates the convergence of ER stress with oxidative stress signaling. Here we discuss progress regarding the signaling pathways involved in these cellular stresses and the implications of the intersection between the two signaling pathways. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:317 / 332
页数:16
相关论文
共 177 条
[1]   Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene [J].
Alam, J ;
Stewart, D ;
Touchard, C ;
Boinapally, S ;
Choi, AMK ;
Cook, JL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (37) :26071-26078
[2]   Oxidative stress in neurodegeneration: cause or consequence? [J].
Andersen, JK .
NATURE MEDICINE, 2004, 10 (07) :S18-S25
[3]   ERYTHROID TRANSCRIPTION FACTOR NF-E2 IS A HEMATOPOIETIC-SPECIFIC BASIC LEUCINE ZIPPER PROTEIN [J].
ANDREWS, NC ;
ERDJUMENTBROMAGE, H ;
DAVIDSON, MB ;
TEMPST, P ;
ORKIN, SH .
NATURE, 1993, 362 (6422) :722-728
[4]   Defective translational control facilitates vesicular stomatitis virus oncolysis [J].
Balachandran, S ;
Barber, GN .
CANCER CELL, 2004, 5 (01) :51-65
[5]   Inducible dissociation of SCFMet30 ubiquitin ligase mediates a rapid transcriptional response to cadmium [J].
Barbey, R ;
Baudouin-Cornu, P ;
Lee, TA ;
Rouillon, A ;
Zarzov, P ;
Tyers, M ;
Thomas, D .
EMBO JOURNAL, 2005, 24 (03) :521-532
[6]   Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2α kinase [J].
Berlanga, JJ ;
Santoyo, J ;
de Haro, C .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 265 (02) :754-762
[7]   Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response [J].
Bertolotti, A ;
Zhang, YH ;
Hendershot, LM ;
Harding, HP ;
Ron, D .
NATURE CELL BIOLOGY, 2000, 2 (06) :326-332
[8]   Activating transcription factor 4 is translationally regulated by hypoxic stress [J].
Blais, JD ;
Filipenko, V ;
Bi, MX ;
Harding, HP ;
Ron, D ;
Koumenis, C ;
Wouters, BG ;
Bell, JC .
MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (17) :7469-7482
[9]   Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound [J].
Braun, S ;
Hanselmann, C ;
Gassmann, MG ;
Keller, UAD ;
Born-Berclaz, C ;
Chan, KM ;
Kan, YW ;
Werner, S .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (15) :5492-5505
[10]   PERK mediates cell-cycle exit during the mammalian unfolded protein response [J].
Brewer, JW ;
Diehl, JA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12625-12630