Two new cytotoxic sesquiterpenoids from Eupatorium lindleyanum DC.

被引：22

作者：

Huo, J ^{[1
]}

Yang, SP ^{[1
]}

Ding, J ^{[1
]}

Yue, JM ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

JOURNAL OF INTEGRATIVE PLANT BIOLOGY | 2006年 / 48卷 / 04期

关键词：

eupalinilides K and L; Eupatorium lindleyanum; sesquiterpenoid;

D O I：

10.1111/j.1744-7909.2006.00226.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Two new sesquiterpenoid lactones, namely eupalinilides K and L, were isolated from Eupatorium lindleyanum DC. Their structures were determined by spectral methods, including 1D- and 2D-NMR spectra. Cytotoxic evaluation showed that eupalinilide L exhibited potent cytotoxicity against P-388 and A-549 tumor cell lines with IC50 values of 0.17 and 2.60 mu mol/L, respectively.

引用

页码：473 / 477

页数：5

共 7 条

[1]

Editorial Committee of the Administration Bureau of Traditional Chinese Medicine, 1998, CHIN MAT MED, P839

[2]

Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum [J].

Huo, J ;

Yang, SP ;

Ding, J ;

Yue, JM .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (09) :1470-1475

[3]

4 NEW GERMACRANOLIDES FROM EUPATORIUM-LINDLEYANUM DC [J].

ITO, K ;

SAKAKIBARA, Y ;

HARUNA, M ;

LEE, KH .

CHEMISTRY LETTERS, 1979, (12) :1469-1472

[4]

EUDESMANOLIDES, TRICHOMATOLIDES B-E, AND A HELIANGOLIDE FROM CALEA-TRICHOMATA [J].

OBER, AG ;

QUIJANO, L ;

FISCHER, NH .

PHYTOCHEMISTRY, 1984, 23 (07) :1439-1443

[5]

CHEMISTRY OF HELIANTHUS .3. SESQUITERPENE LACTONES AND DITERPENE CARBOXYLIC-ACIDS IN HELIANTHUS-NIVEUS SUBSPECIES CANESCENS [J].

OHNO, N ;

MABRY, TJ .

PHYTOCHEMISTRY, 1980, 19 (04) :609-614

[6]

ANTITUMOR AGENTS .109. THE CYTOTOXIC PRINCIPLES OF PSEUDOLARIX-KAEMPFERI - PSEUDOLARIC ACID-A AND ACID-B AND RELATED DERIVATIVES [J].

PAN, DJ ;

LI, ZL ;

HU, CQ ;

CHEN, K ;

CHANG, JJ ;

LEE, KH .

PLANTA MEDICA, 1990, 56 (04) :383-385

[7]

Comparison of the sulforhodamine B assay and the clonogenic assay for in vitro chemoradiation studies [J].

Pauwels, B ;

Korst, AEC ;

de Pooter, CMJ ;

Pattyn, GGO ;

Lambrechts, HAJ ;

Baay, MFD ;

Lardon, F ;

Vermorken, JB .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2003, 51 (03) :221-226

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