Neurodevelopmental processes in the ontogenesis and epigenesis of psychopathology

被引:82
作者
Cicchetti, D
Cannon, TD
机构
[1] Univ Rochester, Mt Hope Family Ctr, Rochester, NY 14608 USA
[2] Univ Calif Los Angeles, Los Angeles, CA USA
关键词
D O I
10.1017/S0954579499002114
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Dramatic gains in knowledge have been made in the fields of neuroscience, human development, and developmental psychopathology during the past quarter of a century. Despite the advances that have been achieved in each discipline separately, considerably less progress has occurred in understanding the relation between neurobiological and behavioral development in normal and atypical populations. Research has increasingly demonstrated that abnormalities that occur early in development may result in the emergence of aberrant neural circuitry that eventuates in relatively enduring forms of psychopathology. Knowledge of normal neurobiological development provides a powerful foundation for understanding the contributions that neurodevelopmental processes make to the etiology and sequelae of psychopathology across the life course. An integrated perspective wherein an appreciation of the complex neural, psychological, and social-contextual processes that cohere to bring about normal and pathological outcomes is necessary in order to advance understanding of the genesis and epigenesis of mental disorders. Such an approach will require a reduction of the schisms that so often separate neurobiological and behavioral research.
引用
收藏
页码:375 / 393
页数:19
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