Suppression of macrophage responses to bacterial lipopolysaccharide by a non-secretory form of secretory leukocyte protease inhibitor

被引：28

作者：

Zhu, J ^{[1
]}

Nathan, C ^{[1
]}

Ding, AH ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1999年 / 1451卷 / 2-3期

关键词：

protease inhibitor; secretory leukocyte protease inhibitor; bacterial lipopolysaccharide; macrophage activation;

D O I：

10.1016/S0167-4889(99)00111-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of secretory leukocyte protease inhibitor (SLPI) suppresses the ability of macrophages to respond to bacterial lipoyolysaccharide (LPS). Here, addition of recombinant or native SLPI to the extracellular medium was non-suppressive, while transfection with a non-secretory form of SLPI was fully suppressive, an effect overcome by treatment with interferon-gamma. A portion of the SLPI produced by untransfected macrophages was localized in the cytosol. Thus, SLPI can act intracellularly to block macrophage activation by LPS. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：219 / 223

页数：5

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