Palladium-Catalyzed Annulation of Acyloximes with Arynes (or Alkynes) Synthesis of Phenanthridines and Isoquinolines

被引：272

作者：

Gerfaud, Thibaud ^{[1
]}

Neuville, Luc ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 03期

关键词：

arynes; domino reactions; heterocycles; oximes; palladium; HIGHLY EFFICIENT ROUTE; O BOND-CLEAVAGE; ARYL HALIDES; AMINO-HECK; PYRROLE DERIVATIVES; OXIDATIVE AMINATION; 2+2+2 COCYCLIZATION; ORGANIC-SYNTHESIS; N-ARYLATION; CYCLIZATION;

D O I：

10.1002/anie.200804683

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Intermolecular insertion: A palladium-catalyzed domino aminopalladation/C-H functionalization sequence has been developed, and provides access to functionalized phenanthridines and isoquinolines (see scheme; Tf = triflate, TMS = trimethylsilyl, M.S. = molecular sieves). The use of butyronitrile as the solvent is determinant to the success of the domino process. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：572 / 577

页数：6

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