Anomalous diffusion probes microstructure dynamics of entangled F-actin networks

被引：509

作者：

Wong, IY ^{[1
]}

Gardel, ML

Reichman, DR

Weeks, ER

Valentine, MT

Bausch, AR

Weitz, DA

机构：

[1] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

[2] Harvard Univ, DEAS, Cambridge, MA 02138 USA

[3] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

[4] Emory Univ, Dept Phys, Atlanta, GA 30322 USA

[5] Tech Univ Munich, Lehrstuhl Biophys E22, D-8046 Garching, Germany

来源：

PHYSICAL REVIEW LETTERS | 2004年 / 92卷 / 17期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1103/PhysRevLett.92.178101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We study the thermal motion of colloidal tracer particles in entangled actin filament (F-actin) networks, where the particle radius is comparable to the mesh size of the F-actin network. In this regime, the ensemble-averaged mean-squared displacement of the particles is proportional to tau(gamma), where 0<gamma<1 from 0.1<tau<100 s and depends only on the ratio of the probe radius to mesh size. By directly imaging hundreds of particles over 20 min, we determine this anomalous subdiffusion is due to the dynamics of infrequent and large jumps particles make between distinct pores in the network.

引用

页码：178101 / 1

页数：4

共 26 条

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