Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation

被引：15

作者：

Kim, Won Sam ^{[1
,3
]}

Kim, Dong Oh ^{[1
,3
]}

Yoon, Sung Jin ^{[1
,3
]}

Kim, Mi Jeong ^{[1
,3
]}

Yoon, Suk Ran ^{[1
]}

Park, Young-Jun ^{[1
]}

Jung, Haiyoung ^{[1
]}

Kim, Tae-Don ^{[1
]}

Kwon, Byoung-Mog ^{[2
,3
]}

Choi, Inpyo ^{[1
,3
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Immunotherapy Res Ctr, Taejon 305600, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Lab Chem Genom & Biol, Taejon 305600, South Korea

[3] Univ Sci & Technol, Dept Funct Genom, Taejon 305333, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 425卷 / 02期

关键词：

Cryptotanshinone; Tanshinone IIA; NK cells; Differentiation; Id2; TRANSCRIPTION FACTOR; DEVELOPMENTAL PATHWAYS; GAMMA PRODUCTION; T-BET; EXPRESSION; NK; INTERLEUKIN-15; DEFICIENCY; ACTIVATION; MATURATION;

D O I：

10.1016/j.bbrc.2012.07.093

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinone (CTS) and tanshinone IIA (TS), isolated from Salvia miltiorrhiza Bunge, on the differentiation of NK cells. In the presence of IL-15, tanshinones increased NK cell maturation, NK cell differentiation and the expression of several transcription factors, including Id2, GATA3, T-bet, and Ets-1. Additionally, tanshinones increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, the p38 inhibitor SB203580 blocked the developmental effects of the tanshinones and suppressed Id2, T-bet, and Ets-1 expression during NK cell differentiation. These results suggest that tanshinones significantly increased IL-15-induced NK cell differentiation via enhancing the p38 phosphorylation and the expression of transcription factors. (c) 2012 Elsevier Inc. All rights reserved.

引用

页码：340 / 347

页数：8

共 33 条

[1]

The Ets-1 transcription factor is required for the development of natural killer cells in mice [J].