ROCK as a Therapeutic Target of Diabetic Retinopathy

被引：28

作者：

Arita, Ryoichi ^{[1
]}

Hata, Yasuaki ^{[1
]}

Ishibashi, Tatsuro ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Higashi Ku, Fukuoka 8128582, Japan

来源：

JOURNAL OF OPHTHALMOLOGY | 2010年 / 2010卷

关键词：

PROLIFERATIVE VITREORETINAL DISEASES; RHO-KINASE INHIBITOR; ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE; POSSIBLE INVOLVEMENT; CELL-SURVIVAL; FASUDIL; ADHESION; CONTRACTION; ACTIVATION;

D O I：

10.1155/2010/175163

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

The increasing global prevalence of diabetes is a critical problem for public health. In particular, diabetic retinopathy, a prevalent ocular complication of diabetes mellitus, causes severe vision loss in working population. A better understanding of the pathogenesis and the development of new pharmacologic treatments are needed. This paper describes the relevance between Rho/ROCK pathway and the pathogenesis of diabetic retinopathy from its early to late stages. Moreover, the therapeutic potential of ROCK inhibitor in the total management of diabetic retinopathy is discussed.

引用

页数：9

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