Advances in nanotechnology-based delivery systems for curcumin

被引：29

作者：

Sun, Min ^{[1
,2
]}

Su, Xun ^{[1
]}

Ding, Buyun ^{[1
]}

He, Xiuli ^{[3
]}

Liu, Xiuju ^{[4
]}

Yu, Aihua ^{[1
]}

Lou, Hongxiang ^{[5
]}

Zhai, Guangxi ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China

[2] Cent Hosp Zibo, Dept Pharm, Zibo 255036, Peoples R China

[3] Shandong Med Inst, Affiliated Hosp, Dept Pharm, Jinan 250031, Peoples R China

[4] Shandong Prov Hosp, Dept Pharm, Jinan 250022, Peoples R China

[5] Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Jinan 250012, Peoples R China

来源：

NANOMEDICINE | 2012年 / 7卷 / 07期

关键词：

bioavailability; biological activity; curcumin; nanotechnology; CHEMOPREVENTIVE AGENT CURCUMIN; LIPOSOME-ENCAPSULATED CURCUMIN; PH-SENSITIVE NANOPARTICLES; PROSTATE-CANCER CELLS; DRUG-DELIVERY; IN-VITRO; COLON-CANCER; PHOSPHOLIPID COMPLEX; POLYMERIC IMPLANTS; TOXICOLOGICAL EVALUATION;

D O I：

10.2217/NNM.12.80

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Curcumin (CUR), a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of CUR in inflammatory disorders, cardiovascular disease, cancer, Alzheimer's disease and neurological disorders have been shown. However, the clinical application of CUR is severely limited by its main drawbacks such as instability, low solubility, poor bioavailability and rapid metabolism. Multifarious nanotechnology-based delivery approaches have been used to enhance the oral bioavailability, biological activity or tissue-targeting ability of CUR. This article reviews potential novel drug delivery systems for CUR including liposomes, polymeric nanoparticles, solid lipid nanoparticles, micelles, nanogels, nanosuspensions, nanoemulsions, complexes and dendrimer/dimer, which provide promising results for CUR to improve its biological activities.

引用

页码：1085 / 1100

页数：16

共 99 条

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Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice [J].