Fibrinolysis in disseminated intravascular coagulation

被引：51

作者：

Hack, CE

机构：

[1] Univ Amsterdam, Netherlands Red Cross, Blood Transfus Serv, Cent Lab,Lab Expt & Clin Immunol, NL-1066 CX Amsterdam, Netherlands

[2] Free Univ Amsterdam Hosp, Dept Clin Chem, Amsterdam, Netherlands

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2001年 / 27卷 / 06期

关键词：

fibrinolysis; sepsis; plasminogen activator inhibitor type 1; PAI-1; plasminogen activators; multiple organ failure syndrome; MOFS;

D O I：

10.1055/s-2001-18867

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies in experimental models for sepsis, the most common cause of disseminated intravascular coagulation (DIC), have put forward the concept of a procoagulant state that is characterized by thrombin generation exceeding that of plasmin. Convincing evidence indicates that this imbalance between coagulation and fibrinolysis is due to increased levels of plasminogen activator inhibitor type 1 (PAI-1). Levels of this fibrinolysis inhibitor indeed correlate with outcome and severity of multiple organ failure in patients with sepsis, as well as in patients with DIC from other causes. Hence we suggest that PAI-1 constitutes an important target for therapy in patients with DIC.

引用

页码：633 / 638

页数：6

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