Thiol addition to protected allyl glycosides: An improved method for the preparation of spacer-arm glycosides

被引：41

作者：

vanSeeventer, PB ^{[1
]}

vanDorst, JALM ^{[1
]}

Siemerink, JF ^{[1
]}

Kamerling, JP ^{[1
]}

Vliegenthart, JFG ^{[1
]}

机构：

[1] UNIV UTRECHT,BIJVOET CTR,DEPT BIOORGAN CHEM,NL-3508 TB UTRECHT,NETHERLANDS

来源：

CARBOHYDRATE RESEARCH | 1997年 / 300卷 / 04期

关键词：

neoglycoconjugates; allyl glycosides; sulfide spacer-arm; 3-(2-azidoethylthio)propyl glycosides;

D O I：

10.1016/S0008-6215(97)00074-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A useful method for the preparation of differently functionalized sulfide spacer-arm glycosides is presented. Several protected allyl glycosides were variously elongated via a radical addition reaction with pentanethiol, methyl 3-mercaptopropionate, or 2-mercaptoethanol. The hydroxyl function of protected 3-(2-hydroxyethylthio)propyl glycosides was subsequently transformed into an azide function. (C) 1997 Elsevier Science Ltd.

引用

页码：369 / 373

页数：5

共 17 条

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