Old Livers C/EBPα Meets New Partners

被引：6

作者：

Timchenko, Nikolai A. ^{[1
]}

机构：

[1] Baylor Coll Med, Huffington Ctr Aging, One Baylor Plaza, Houston, TX 77030 USA

来源：

CELL CYCLE | 2003年 / 2卷 / 05期

关键词：

aging; liver proliferation; cell cycle; transcription factors;

D O I：

10.4161/cc.2.5.467

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The aging liver looses the ability to proliferate after partial hepatic resections. We have recently found that, in liver, aging switches C/EBP alpha from inhibition of Cdks to repression of E2F, the pathway that normally operates in adipose tissues. This switch causes a loss of proliferative response in old livers because of an inability to induce E2F target genes after partial hepatectomy.

引用

页码：445 / 446

页数：2

共 11 条

[1]

BUCHER NLR, 1964, CANCER RES, V24, P509

[2] C/EBPβ phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival [J].

Buck, M ;

Poli, V ;

Hunter, T ;

Chojkier, M .

MOLECULAR CELL, 2001, 8 (04) :807-816

[3] Aging reduces proliferative capacities of liver by switching pathways of C/EBPα growth arrest [J].

Iakova, P ;

Awad, SS ;

Timchenko, NA .

CELL, 2003, 113 (04) :495-506

[4] McBindall - A better name for CCAAT/enhancer binding proteins? [J].

McKnight, SL .

CELL, 2001, 107 (03) :259-261

[5] E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo [J].

Porse, BT ;

Pedersen, TÅ ;

Xu, XF ;

Lindberg, B ;

Wewer, UM ;

Friis-Hansen, L ;

Nerlov, C .

CELL, 2001, 107 (02) :247-258

[6] Altered control of cellular proliferation in the absence of mammalian brahma (SNF2α) [J].

Reyes, JC ;

Barra, J ;

Muchardt, C ;

Camus, A ;

Babinet, C ;

Yaniv, M .

EMBO JOURNAL, 1998, 17 (23) :6979-6991

[7] CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice [J].

Timchenko, NA ;

Harris, TE ;

Wilde, M ;

Bilyeu, TA ;

BurgessBeusse, BL ;

Finegold, MJ ;

Darlington, GJ .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (12) :7353-7361

[8] C/EBPα triggers proteasome-dependent degradation of cdk4 during growth arrest [J].

Wang, HM ;

Goode, T ;

Iakova, P ;

Albrecht, JH ;

Timchenko, NA .

EMBO JOURNAL, 2002, 21 (05) :930-941

[9] C/EBPα arrests cell proliferation through direct inhibition of cdk2 and cdk4 [J].

Wang, HM ;

Iakova, P ;

Wilde, M ;

Welm, A ;

Goode, T ;

Roesler, WJ ;

Timchenko, NA .

MOLECULAR CELL, 2001, 8 (04) :817-828

[10] Increased hepatic forkhead box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27KiP1 protein levels and increased Cdc25B expression [J].

Wang, XH ;

Krupczak-Hollis, K ;

Tan, YJ ;

Dennewitz, MB ;

Adami, GR ;

Costa, RH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (46) :44310-44316

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