Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit

被引：129

作者：

Damljanovic, Ivan ^{[1
]}

Vukicevic, Mirjana ^{[1
]}

Radulovic, Niko ^{[2
]}

Palic, Radosav ^{[2
]}

Ellmerer, Ernst ^{[3
]}

Ratkovic, Zoran ^{[1
]}

Joksovic, Milan D. ^{[1
]}

Vukicevic, Rastko D. ^{[1
]}

机构：

[1] Univ Kragujevac, Fac Sci, Dept Chem, Kragujevac 34000, Serbia

[2] Univ Nis, Fac Sci & Math, Dept Chem, Nish 18000, Serbia

[3] Univ Innsbruck, Inst Organ Chem, A-6020 Innsbruck, Austria

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 04期

关键词：

Vilsmeier-Haack reaction; Ferrocenylpyrazoles; Antimicrobial screening; ANTITUMOR-ACTIVITY; BIOLOGICAL-ACTIVITY; ANTIMALARIAL ACTIVITY; PYRROLNITRIN ANALOGS; IN-VITRO; IDENTIFICATION; NUCLEOSIDES; CHEMISTRY; DESIGN; AGENTS;

D O I：

10.1016/j.bmcl.2009.01.006

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A series of new imines and amines have been synthesized by condensation of 1H-3-ferrocenyl-1-phenyl-pyrazole-4-carboxaldehyde with the corresponding amines, followed by reduction with sodium borohydride. The synthesized compounds have been screened for their in vitro antimicrobial activity against 11 bacteria and three fungal/yeast strains, using disc diffusion and broth microdilution susceptibility assays. They have shown a wide range of activities, from completely inactive to the highly active compounds. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1093 / 1096

页数：4

共 45 条

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Development of organometallic (organo-transition metal) pharmaceuticals [J].