Toxic effects of ultraviolet radiation on the skin

被引:897
作者
Matsumura, Y
Ananthaswamy, HN
机构
[1] Kansai Med Univ, Dept Dermatol, Moriguchi, Osaka 5708507, Japan
[2] Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
ultraviolet radiation; photoproducts; skin cancer;
D O I
10.1016/j.taap.2003.08.019
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Ultraviolet (UV) irradiation present in sunlight is an environmental human carcinogen. The toxic effects of UV from natural sunlight and therapeutic artificial lamps are a major concern for human health. The major acute effects of UV irradiation on normal human skin comprise sunburn inflammation (erythema), tanning, and local or systemic immunosuppression. At the molecular level, UV irradiation causes DNA damage such as cyclobutane pyrimidine dimers and (6-4) photoproducts, which are usually repaired by nucleotide excision repair (NER). Chronic exposure to UV irradiation leads to photoaging, immunosuppression, and ultimately photocarcinogenesis. Photocarcinogenesis involves the accumulation of genetic changes, as well as immune system modulation, and ultimately leads to the development of skin cancers. In the clinic, artificial lamps emitting UVB (280-320 nm) and UVA (320-400 nm) radiation in combination with chemical drugs are used in the therapy of many skin diseases including psoriasis and vitiligo. Although such therapy is beneficial, it is accompanied with undesirable side effects. Thus, UV radiation is like two sides of the same coin-on one side, it has detrimental effects, and on the other side, it has beneficial effects. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:298 / 308
页数:11
相关论文
共 108 条
[1]  
ANANTHASWAMY HN, 1997, CHEM CARCINOGENS ANT, V12, P255
[2]  
[Anonymous], 1976, PIGMENT CELL
[3]   IDENTIFICATION OF THE MOLECULAR TARGET FOR THE SUPPRESSION OF CONTACT HYPERSENSITIVITY BY ULTRAVIOLET-RADIATION [J].
APPLEGATE, LA ;
LEY, RD ;
ALCALAY, J ;
KRIPKE, ML .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1117-1131
[4]   Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L [J].
Aragane, Y ;
Kulms, D ;
Metze, D ;
Wilkes, G ;
Pöppelmann, B ;
Luger, TA ;
Schwarz, T .
JOURNAL OF CELL BIOLOGY, 1998, 140 (01) :171-182
[5]   RAS GENES [J].
BARBACID, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827
[6]   Role of immunomodulation in diseases responsive to phototherapy [J].
Beissert, S ;
Schwarz, T .
METHODS, 2002, 28 (01) :138-144
[7]  
BOS JL, 1989, CANCER RES, V49, P4682
[8]   SEQUENCE SPECIFICITY IN PHOTOREACTION OF VARIOUS PSORALEN DERIVATIVES WITH DNA - ROLE IN BIOLOGICAL-ACTIVITY [J].
BOYER, V ;
MOUSTACCHI, E ;
SAGE, E .
BIOCHEMISTRY, 1988, 27 (08) :3011-3018
[9]   HIGH SINGLE-DOSE EUROPEAN PUVA REGIMEN ALSO CAUSES AN EXCESS OF NONMELANOMA SKIN-CANCER [J].
BRUYNZEEL, I ;
BERGMAN, W ;
HARTEVELT, HM ;
KENTER, CCA ;
VANDEVELDE, EA ;
SCHOTHORST, AA ;
SUURMOND, D .
BRITISH JOURNAL OF DERMATOLOGY, 1991, 124 (01) :49-55
[10]   ASSIGNMENT OF A LOCUS FOR FAMILIAL MELANOMA, MLM, TO CHROMOSOME-9P13-P22 [J].
CANNONALBRIGHT, LA ;
GOLDGAR, DE ;
MEYER, LJ ;
LEWIS, CM ;
ANDERSON, DE ;
FOUNTAIN, JW ;
HEGI, ME ;
WISEMAN, RW ;
PETTY, EM ;
BALE, AE ;
OLOPADE, OI ;
DIAZ, MO ;
KWIATKOWSKI, DJ ;
PIEPKORN, MW ;
ZONE, JJ ;
SKOLNICK, MH .
SCIENCE, 1992, 258 (5085) :1148-1152