Genetic characterization of the Guinea-Bissau family of Mycobacterium tuberculosis complex strains

被引：10

作者：

Koivula, T

Ekman, M

Leitner, T

Löfdahl, S

Ghebremicahel, S

Mostowy, S

Behr, MA

Svenson, SB

Källenius, G

机构：

[1] Swedish Inst Infect Dis Control, S-17182 Solna, Sweden

[2] McGill Univ, Ctr Hlth, Montreal, PQ, Canada

[3] Swedish Univ Agr Sci, Dept Vet Bacteriol, S-75123 Uppsala, Sweden

[4] Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 03期

关键词：

tuberculosis; Africa; evolution;

D O I：

10.1016/j.micinf.2003.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a previous study of Mycobacterium tuberculosis complex isolates from Guinea-Bissau in West Africa, we identified a unique group of strains, designated here as the Guinea-Bissau family of strains, which, although genotypically closely related, phenotypically demonstrated a considerable heterogeneity. We conducted here a detailed genotypic analysis of a subset (n=35) of these isolates. Based on the data obtained, and by comparison of known corresponding genes in mycobacteria outside the M. tuberculosis complex, we propose that the Guinea-Bissau strains belong to a unique branch of the M. tuberculosis complex tree in between classical M. tuberculosis and classical M. bovis. These observations are discussed in their significance in M. tuberculosis complex classification. (C) 2004 Elsevier SAS. All rights reserved.

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页码：272 / 278

页数：7

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