Cannabinoids in medicine: A review of their therapeutic potential

被引:337
作者
Amar, MB
机构
[1] Univ Montreal, Substance Abuse Program, Fac Continuing Educ, Montreal, PQ H3C 3J7, Canada
[2] Univ Montreal, Substance Abuse Program, Fac Grad Studies, Montreal, PQ H3C 3J7, Canada
关键词
cannabinoids; cannabis; therapeutic potential; controlled clinical trials; efficacy; safety;
D O I
10.1016/j.jep.2006.02.001
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
In order to assess the current knowledge on the therapeutic potential of cannabinoids, a meta-analysis was performed through Medline and PubMed up to July 1, 2005. The key words used were cannabis, rnarijuana, marihuana, hashish, hashich, haschich, cannabinoids, tetrahydrocannabinol, THC, dronabinol, nabilone, levonantradol, randomised, randomized, double-blind, simple blind, placebo-controlled. and human. The research also included the reports and reviews published in English, French and Spanish. For the final selection, only properly controlled clinical trials were retained, thus open-label studies were excluded. Seventy-two controlled studies evaluating the therapeutic effects of cannabinoids were identified. For each clinical trial, the country where the project was held, the number of patients assessed, the type of study and comparisons done, the products and the dosages used, their efficacy and their adverse effects are described. Cannabinoids present an interesting therapeutic potential as antiemetics, appetite stimulants in debilitating diseases (cancer and AIDS), analgesics, and in the treatment of multiple sclerosis, spinal cord injuries, Tourette's syndrome, epilepsy and glaucoma. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
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页码:1 / 25
页数:25
相关论文
共 165 条
[1]   Short-term effects of cannabinoids in patients with HIV-1 infection - A randomized, placebo-controlled clinical trial [J].
Abrams, DI ;
Hilton, JF ;
Leiser, RJ ;
Shade, SB ;
Elbeik, TA ;
Aweeka, FT ;
Benowitz, NL ;
Bredt, BM ;
Kosel, B ;
Aberg, JA ;
Deeks, SG ;
Mitchell, TF ;
Mulligan, K ;
Bacchetti, P ;
McCune, JM ;
Schambelan, M .
ANNALS OF INTERNAL MEDICINE, 2003, 139 (04) :258-266
[2]   ANTI-EMETIC EFFICACY AND TOXICITY OF NABILONE, A SYNTHETIC CANNABINOID, IN LUNG-CANCER CHEMOTHERAPY [J].
AHMEDZAI, S ;
CARLYLE, DL ;
CALDER, IT ;
MORAN, F .
BRITISH JOURNAL OF CANCER, 1983, 48 (05) :657-663
[3]  
[Anonymous], 1981, J CLIN PHARMACOL, DOI DOI 10.1002/j.1552-4604.1981.tb02576.x
[4]  
[Anonymous], SCI MARIJUANA
[5]  
[Anonymous], 2003, JAMA-J AM MED ASSOC
[6]  
[Anonymous], BRIT MED J
[7]  
[Anonymous], 2002, J PALLIAT CARE
[8]  
[Anonymous], MARIHUANA CANNABINOI
[9]  
[Anonymous], 2002, CANNABIS OUR POSITIO
[10]  
[Anonymous], 1980, PHARMACOLOGY