Cytotoxic terpenoids from Juglans sinensis leaves and twigs

被引：28

作者：

Yang, Heejung ^{[1
,2
]}

Cho, Hyun-Jong ^{[1
,2
]}

Sim, So Hee ^{[3
]}

Chung, Young Keun ^{[3
]}

Kim, Dae-Duk ^{[1
,2
]}

Sung, Sang Hyun ^{[1
,2
]}

Kim, Jinwoong ^{[1
,2
]}

Kim, Young Choong ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[3] Seoul Natl Univ, Dept Chem, Seoul 151742, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 05期

关键词：

Juglans sinensis; Triterpenes; Sesquiterpenes; Oleanane; Ursane; Eudesmane; C-13; NMR-SPECTRA; CONSTITUENTS; DERIVATIVES; EXTRACTS; ACID; H-1;

D O I：

10.1016/j.bmcl.2012.01.010

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Bioassay-guided fractionation of an 80% MeOH extract of Juglan sinensis leaves and twigs has resulted in the isolation of three new triterpenes (1-3) and two new sesquiterpenes (4-5) along with two known sesquiterpenes (6-7). The new compounds were determined to be 3 beta, 11 alpha, 19 alpha, 24, 30-pentahydroxy-20 beta, 28-epoxy-28 beta-methoxy-ursane (1), 1 alpha, 3 beta-dihydroxy-olean-18-ene (2), 2 alpha, 3 alpha, 23-trihydroxy-urs-12-en-28-oic acid 28-O-beta-D-glucopyranoside (3), (4S, 5S, 7R, 8R, 14R)-8, 11-dihydroxy-2, 4-cyclo-eudesmane (4), 15-hydroxy-alpha-eudesmol-11-O-beta-D-glucopyranoside (5), by spectroscopic analysis. The cytotoxicity of compounds (1-7) against four cancer cell lines such as B16F10, Hep-2, MCF-7 and U87-MG was evaluated. Compounds 1, 2, 6 and 7 showed potent cytotoxicity against all of four cancer cell lines, respectively. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2079 / 2083

页数：5

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