Tying loose ends: Roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks

被引：123

作者：

Lieber, MR

Grawunder, U

Wu, XT

Yaneva, M

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,DEPT MOL BIOPHYS,ST LOUIS,MO 63110

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(97)80116-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A convergence of information from biochemistry, yeast and mammalian genetics, immunology, and radiation biology has permitted identification of some of the protein participants Ku, DNA-PK, XRCC4 - and the reaction intermediates in DNA end joining, suggesting how broken chromosomal ends may be recognized and repaired in eukaryotic cells. Some components may be defective in inherited disorders.

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页码：99 / 104

页数：6

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