Nationwide surveillance of antimicrobial resistance among Enterobacteriaceae in intensive care units in Taiwan

被引：24

作者：

Jean, S. -S.

Hsueh, P. -R. ^{[1
,13
]}

Lee, W. -S. ^{[2
]}

Chang, H. -T.

Chou, M. -Y. ^{[3
]}

Chen, I. -S.

Wang, J. -H. ^{[4
]}

Lin, C. -F. ^{[5
]}

Shyr, J. -M. ^{[6
]}

Ko, W. -C. ^{[7
]}

Wu, J. -J. ^{[8
]}

Liu, Y. -C. ^{[9
]}

Huang, W. -K. ^{[10
]}

Teng, L. -J. ^{[11
]}

Liu, C. -Y. ^{[12
]}

机构：

[1] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Internal Med, Coll Med, Taipei 100, Taiwan

[2] Taipei Municipal WanFang Hosp, Dept Internal Med, Taipei, Taiwan

[3] Cheng Hsin Rehabil Med Ctr, Dept Internal Med, Taipei, Taiwan

[4] China Med Coll Hosp, Dept Internal Med, Taichung, Taiwan

[5] Taichung Vet Gen Hosp, Dept Internal Med, Taichung, Taiwan

[6] Taichung Vet Gen Hosp, Dept Clin Pathol, Taichung, Taiwan

[7] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 70428, Taiwan

[8] Natl Cheng Kung Univ, Coll Med, Sch Med Technol, Tainan 70101, Taiwan

[9] Kaohsiung Vet Gen Hosp, Dept Clin Pathol, Kaohsiung, Taiwan

[10] Kaohsiung Vet Gen Hosp, Dept Internal Med, Kaohsiung, Taiwan

[11] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Sch Med Technol, Taipei 10764, Taiwan

[12] Taipei Vet Gen Hosp, Dept Internal Med, Taipei, Taiwan

[13] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Lab Med, Coll Med, Taipei 100, Taiwan

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2009年 / 28卷 / 02期

关键词：

ESCHERICHIA-COLI; BETA-LACTAMASES; PATHOGENS; ERTAPENEM; AMERICA;

D O I：

10.1007/s10096-008-0610-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

To determine the antimicrobial resistance profiles among clinical isolates of Enterobacteriaceae in Taiwanese intensive care units (ICUs), a national surveillance of antibiotic resistance among important Enterobacteriaceae was conducted from September 2005 through November 2005 at the ICUs of ten major teaching hospitals in Taiwan. A total of 574 Enterobacteriaceae isolates recovered from various clinical samples of our ICU patients were submitted for in vitro test. Minimum inhibitory concentrations (MICs) of these isolates to 18 antimicrobial agents were determined by the broth microdilution method. The prevalences of Enterobacteriaceae isolates with phenotypic extended-spectrum beta-lactamase (ESBL) production were 26% in Klebsiella pneumoniae, 16% in Serratia marcescens, 14% in Escherichia coli, and 13% in Proteus mirabilis, in which a significantly rising prevalence of ESBL production among K. pneumoniae was noted (p = 0.002) when compared with a previous Taiwanese survey in 2000. Heterogeneous resistance to various fluoroquinolones was found among our Enterobacteriaceae isolates, except for Entetrobacter cloacae. Emergence of ertapenem-resistant isolates of E. coli, K. pneumoniae, E. cloacae, and S. marcescens was noted. Gradually increasing rates of drug-resistant Enterobacteriaceae were noted in Taiwanese ICUs. Periodic surveillance of the evolutionary trend of antimicrobial resistance among ICU isolates is crucial for starting appropriately empirical antimicrobial therapy in the future.

引用

页码：215 / 220

页数：6

共 10 条

[1]

[Anonymous], M7A6 CLSI

[2]

Clinical and Laboratory Standards Institute, 2005, M100S15 CLSI

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