Synthesis of azolylalkylquinolines with cytotoxic activity

被引：10

作者：

Abel, MD

Luu, HT

Micetich, RG

Nguyen, DQ

Oreski, AB

Tempest, ML

Daneshtalab, M

机构：

[1] SynPhar Laboratories Inc., Edmonton, Alta. T6E 5V2

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1996年 / 33卷 / 02期

关键词：

D O I：

10.1002/jhet.5570330233

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of various azolylalkylquinoline derivatives in which the nature of the linkage between the quinoline and azolylalkyl moieties of the molecule were altered are described. The compounds were tested for cytotoxic activity towards cancer cells and compound 27 was found to exhibit moderate in vivo activity in a murine sarcoma model.

引用

页码：415 / 420

页数：6