Folates and the fetus

被引：30

作者：

Eskes, TKAB ^{[1
]}

机构：

[1] UNIV NIJMEGEN ST RADBOUD HOSP,DEPT OBSTET & GYNAECOL,NL-6500 HB NIJMEGEN,NETHERLANDS

来源：

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1997年 / 71卷 / 02期

关键词：

folates; fetus; neural tube defects; homocysteine; methionine; 5,10-methylenetetrahydrofolate-reductase;

D O I：

10.1016/S0301-2115(96)02620-6

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

It is proven that folic acid supplied in the periconceptional period can lower the recurrence and occurrence rate of neural tube defects (NTDs). Our research team on prevention of birth defects could demonstrate that folic acid preventable NTDs are partly based on hyperhomocystinemia and a genetic predisposition (mutation of the methylenetetrahydrofolate-reductase gene (MTHFR)). Reduced activity of the folate methylation cycle seems to be an attractive working hypothesis in the aetiology of NTDs. This genetic metabolic defect can be overcome by treatment with folic acid and/or vitamin B-12. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：105 / 111

页数：7

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