Cytotoxic T lymphocyte activation by cross-priming

被引：91

作者：

Heath, WR ^{[1
]}

Carbone, FR

机构：

[1] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

[2] Monash Med Sch, Dept Pathol & Immunol, Prahran, Vic 3050, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(99)80050-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cross-priming represents the induction of cytotoxic T lymphocyte responses to exogenous, usually cell associated, antigens that are captured and re-presented on bone-marrow-derived antigen-presenting cells. For effective cross-priming, cytotoxic T lymphocytes require help from : CD4(+) T cells, which mediate this help indirectly via; modification of the antigen-presenting cell. Recent advances made in research,into the cellular and molecular interactions required for cross-priming have greatly improved our understanding of the antigenic requirements for effective priming and have revealed a role for CD40 and its ligand in the provision of T cell help.

引用

页码：314 / 318

页数：5

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