Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk

被引：17

作者：

Alzate, Juan Fernando ^{[2
]}

Arias, Andres ^{[1
]}

Mollinedo, Faustino ^{[3
]}

Rico, Eva ^{[1
]}

de la Iglesia-Vicente, Janis ^{[3
]}

Jimenez-Ruiz, Antonio ^{[1
]}

机构：

[1] Univ Alcala de Henares, Dept Bioquim & Biol Mol, Madrid 28871, Spain

[2] Univ Antioquia, Fac Med, Dept Microbiol & Parasitol, Medellin, Colombia

[3] Univ Salamanca, Consejo Super Invest Cient, Inst Biol Mol & Celular Canc, Ctr Invest Canc, E-37007 Salamanca, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 10期

关键词：

D O I：

10.1128/AAC.01665-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The alkyl-lysophospholipids edelfosine and miltefosine induce apoptosis in Leishmania infantum promastigotes. The finding that edelfosine-induced cell death can be regulated by the ectopic expression of the antiapoptotic and proapoptotic members of the Bcl-2 family of proteins Bcl-X-L and Hrk suggests that this process is similar to apoptosis in eukaryotic cells.

引用

页码：3779 / 3782

页数：4

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