A mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poly(ethylene glycol) macromer

被引：13

作者：

Chun, MK

Choi, HK

Kang, DW

Kim, OJ

Cho, CS ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Agr Biotechnol, Suwon 441744, South Korea

[2] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

[3] Chosun Univ, Sch Dent, Kwangju 501759, South Korea

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2002年 / 83卷 / 09期

关键词：

mucoadhesive; template polymerization; adhesive force; dissolution rate; glass transition; FTIR; drug delivery systems;

D O I：

10.1002/app.2319

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new mucoadhesive polymer complex was prepared by the template polymerization of acrylic acid with poly(ethylene glycol) macromer (PEGM) as a template polymer. Fourier transform infrared results showed that the poly(acrylic acid) (PAA)/PEGM mucoadhesive polymer complex was formed by hydrogen bonding between the carboxyl groups of PAA and the ether groups of PEGM. The glass-transition temperature of the PAA/PEGM mucoadhesive polymer complexes was shifted to a lower temperature as the repeating unit ratio of PAA/PEGM in the complex decreased. The dissolution rate of the PAA/PEGM mucoadhesive polymer complex was much slower than that of the PAA-/poly(ethylene glycol) (PEG) mucoadhesive polymer complex and was dependent on the pH and molecular weight of PEGM. The mucoadhesive force of the PAA/PEGM mucoadhesive polymer complexes was stronger than that of commercial Carbopol 971P NF and almost the same as that of the PAA/PEG mucoadhesive polymer complex. The PAA/PEGM interpolymer complex seemed to be a better mucoadhesive polymer matrix than the PAA/PEG interpolymer complex. (C) 2002 John Wiley Sons, Inc.

引用

页码：1904 / 1910

页数：7

共 16 条

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