Preparation of a new chiral building block containing a benzylic quaternary stereogenic center and a formal total synthesis of (-)-physostigmine

被引：27

作者：

Asakawa, Kaori ^{[1
]}

Noguchi, Naoyoshi ^{[1
]}

Takashima, Shingo ^{[1
]}

Nakada, Masahisa ^{[1
]}

机构：

[1] Waseda Univ, Adv Sch Sci & Engn, Dept Chem & Biochem, Shinjuku Ku, Tokyo 1698555, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2008年 / 19卷 / 19期

关键词：

D O I：

10.1016/j.tetasy.2008.09.021

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This paper describes the preparation of a new chiral building block containing a benzylic quaternary stereogenic center via the highly enantioselective PLE-mediated hydrolysis of dimethyl 2-(2-chloro-5-methoxyphenyl)-2-methylmalonate, as well as the absolute configuration of the new chiral building block, which has been elucidated through the formal total synthesis of (-)-physostigmine. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2304 / 2309

页数：6

共 53 条

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