Synthesis and synthetic applications of 3-amino-Δ5-piperidein-2-ones:: Synthesis of methionine-derived pseudopeptides

被引：15

作者：

Estiarte, MA

de Souza, MVN

del Rio, X

Dodd, RH

Rubiralta, M

Diez, A ^{[1
]}

机构：

[1] Univ Barcelona, Fac Farm, Lab Quim Organ, E-08028 Barcelona, Spain

[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON | 1999年 / 55卷 / 33期

关键词：

peptide mimetics; enamides; lactams; piperideinones;

D O I：

10.1016/S0040-4020(99)00545-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method is described for the efficient preparation of 3-amino-Delta(5)-piperidein-2-ones 3. A synthetic application of enamides 3 has been achieved by methylthiolation on the C5 position to obtain the target methionine-derived pseudopeptides 2. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：10173 / 10186

页数：14

共 21 条

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CHANDRASEKARAN S, 1984, J CHEM RES, P100

[2] Plasma membrane and mitochondrial transport of hepatic reduced glutathione [J].