Do oligodendrocytes divide?

Remyelination occurs in the adult central nervous system following a wide variety of experimental and naturally occurring demyelinating conditions, including multiple sclerosis. Remyelination is preceded by the appearance of new oligodendrocytes. These new cells may be generated from glial precursor cells, or from pre-existing differentiated oligodendrocytes that re-enter the cell cycle, which may first dedifferentiate, or both processes may occur. The evidence for the source of new oligodendrocytes following toxic or immune-mediated lesions is reviewed. Good evidence exists that fully differentiated oligodendrocytes can incorporate [H-3]thymidine but this may be a rare event. Most of the evidence points towards glial precursor cells as the source of new oligodendrocytes in the adult, but definitive experiments have not yet been done. Research strategies, using our current knowledge and techniques, are outlined for solving this problem.