Regulation of Immune Responses by mTOR

被引：643

作者：

Powell, Jonathan D. ^{[1
]}

Pollizzi, Kristen N. ^{[1
]}

Heikamp, Emily B. ^{[1
]}

Horton, Maureen R. ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21231 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 | 2012年 / 30卷

关键词：

CD4; CD8; Tregs; antigen-presenting cells; B cells; metabolism; CELL-CYCLE PROGRESSION; PLASMACYTOID DENDRITIC CELLS; TYPE-1; DIABETIC-PATIENTS; CD8(+) T-CELLS; MAMMALIAN TARGET; CUTTING EDGE; IN-VIVO; B-CELLS; PROTEIN-KINASE; TRANSLATIONAL CONTROL;

D O I：

10.1146/annurev-immunol-020711-075024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in integrating environmental cues in the form of growth factors, amino acids, and energy. In the study of the immune system, mTOR is emerging as a critical regulator of immune function because of its role in sensing and integrating cues from the immune microenvironment. With the greater appreciation of cellular metabolism as an important regulator of immune cell function, mTOR is proving to be a vital link between immune function and metabolism. In this review, we discuss the ability of mTOR to direct the adaptive immune response. Specifically, we focus on the role of mTOR in promoting differentiation, activation, and function in T cells, B cells, and antigen-presenting cells.

引用

页码：39 / 68

页数：30

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