Leukemia inhibitory factor, interleukin 6, and other cytokines using the GP130 transducing receptor: Roles in inflammation and injury

被引：197

作者：

Gadient, RA

Patterson, PH ^{[1
]}

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

[2] Novartis Pharma Res, Transplantat & Gene Therapy, Basel, Switzerland

来源：

STEM CELLS | 1999年 / 17卷 / 03期

关键词：

neuroimmune; arthritis; acute phase; autoimmune; oncostatin M; ciliary neurotrophic factor; leukemia inhibitory factor; interleukin; 6;

D O I：

10.1002/stem.170127

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Inflammation refers to a complex set of mechanisms by which tissues respond to injury and infection. Among the many soluble mediators associated with this process, cytokines are known to be crucial in regulating a variety of cellular and molecular events. Leukemia inhibitory factor (LIF), interleukin 6 (IL-6), IL-11, and possibly other members of this cytokine family are key mediators in various inflammatory processes such as the acute-phase reaction, tissue damage, and infection. These cytokines can act in both pro-inflammatory and anti-inflammatory ways, depending on a number of variables. We emphasize here recent work utilizing knockout mice, which has highlighted the roles of LIF and IL-6, particularly in interactions between the immune and nervous systems.

引用

页码：127 / 137

页数：11

共 171 条

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