Self-eating from an ER-associated cup

被引：24

作者：

Simonsen, Anne

Stenmark, Harald ^{[1
]}

机构：

[1] Univ Oslo, Ctr Canc Biomed, Fac Med, N-0310 Oslo, Norway

来源：

JOURNAL OF CELL BIOLOGY | 2008年 / 182卷 / 04期

关键词：

D O I：

10.1083/jcb.200807061

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since the first morphological description of autophagosomes in the early 1960s, two critical questions have been a matter of intense investigation and debate: what is the origin of the autophagosomal membrane and how is it formed? A study by Axe et al. (E. L. Axe, S. A. Walker, M. Manifava, P. Chandra, H. L. Roderick, A. Habermann, G. Griffiths, and N. T. Ktistakis. 2008. J. Cell Biol. 182: 685-701) provides evidence that cup-shaped protrusions from the endoplasmic reticulum, named omegasomes, serve as platforms for autophagosome biogenesis in mammalian cells.

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收藏

页码：621 / 622

页数：2

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