IFNgR1, a human mycobacterial susceptibility candidate gene

被引：12

作者：

Altare, F

Jouanguy, E

Newport, M

Lamhamedi, S

Fischer, A

Levin, M

Casanova, JL

机构：

[1] HOP NECKER ENFANTS MALAD,INSERM,U429,F-75015 PARIS,FRANCE

[2] ST MARYS HOSP,IMPERIAL COLL,DEPT PEDIAT,LONDON,ENGLAND

来源：

BULLETIN DE L INSTITUT PASTEUR | 1997年 / 95卷 / 03期

关键词：

D O I：

10.1016/S0020-2452(97)81368-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human interferon gamma receptor ligand binding chain (IFN gamma R1) deficiency is an autosomal recessive inherited disorder, Affected children show severe, profound and apparently selective susceptibility to weakly pathogenic mycobacteria, such as bacillus Calmette-Guerin (BCG) and non-tuberculous mycobacteria, This article reviews the evidence supporting a causative relationship between the genotype (IFNgR1 mutations) and the phenotype (mycobacterial infections) of these children.

引用

页码：143 / 146

页数：4

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