Facilitated disassembly of polyplexes composed of self-assembling amphiphilic polycations enhances the gene transfer efficacy

被引：11

作者：

Kitagawa, T

Iwase, R

Ishihara, K

Yamaoka, T ^{[1
]}

Murakami, A

机构：

[1] Kyoto Inst Technol, Dept Polymer Sci & Engn, Sakyo Ku, Kyoto 6068585, Japan

[2] Univ Tokyo, Sch Engn, Dept Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan

来源：

CHEMISTRY LETTERS | 2005年 / 34卷 / 11期

关键词：

D O I：

10.1246/cl.2005.1478

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amphiphilic polycations, p(DMAPAA-co-MPC-co-SA)s, with various cation contents were designed as novel micelle-like nonviral gene carriers. The carriers led to a higher transgene expression in COS-1 cells three times as high as the case of the linear-type polycations. The enhanced transgene expressions were found to be related to the disassembly of plasmid DNA/carrier polyplexes. It can be concluded that a topological factor of the carriers greatly influences on the gene expression efficiency.

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页码：1478 / 1479

页数：2

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