t(r;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma

被引：44

作者：

Fenton, JAL

Schuuring, E

Barrans, SL

Banham, AH

Rollinson, SJ

Morgan, GJ

Jack, AS

van Krieken, JHJM

Kluin, PM

机构：

[1] Univ Leeds, Dept Haematol Oncol, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Groningen, Med Ctr, Dept Pathol & Lab Med, Groningen, Netherlands

[3] Univ Oxford, Nuffield Dept Clin Lab Sci, LRF Immunodiagnost Unit, Oxford, England

[4] Inst Canc Res, Sect Haematooncol, London SW3 6JB, England

[5] Royal Marsden Hosp, London SW3 6JJ, England

[6] Univ St Radboud, Med Ctr, Dept Pathol, Nijmegen, Netherlands

来源：

GENES CHROMOSOMES & CANCER | 2006年 / 45卷 / 02期

关键词：

D O I：

10.1002/gcc.20278

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers. (c) 2005 Wiley-Liss, Inc.

引用

页码：164 / 168

页数：5

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