共 34 条
Resistance to V3-directed neutralization caused by an N-linked oligosaccharide depends on the quaternary structure of the HIV-1 envelope oligomer
被引:74
作者:

Schonning, K
论文数: 0 引用数: 0
h-index: 0
机构: HVIDOVRE UNIV HOSP,DEPT 144,INFECT DIS LAB,DK-2650 HVIDOVRE,DENMARK

Jansson, B
论文数: 0 引用数: 0
h-index: 0
机构: HVIDOVRE UNIV HOSP,DEPT 144,INFECT DIS LAB,DK-2650 HVIDOVRE,DENMARK

Olofsson, S
论文数: 0 引用数: 0
h-index: 0
机构: HVIDOVRE UNIV HOSP,DEPT 144,INFECT DIS LAB,DK-2650 HVIDOVRE,DENMARK

Nielsen, JO
论文数: 0 引用数: 0
h-index: 0
机构: HVIDOVRE UNIV HOSP,DEPT 144,INFECT DIS LAB,DK-2650 HVIDOVRE,DENMARK

Hansen, JES
论文数: 0 引用数: 0
h-index: 0
机构: HVIDOVRE UNIV HOSP,DEPT 144,INFECT DIS LAB,DK-2650 HVIDOVRE,DENMARK
机构:
[1] HVIDOVRE UNIV HOSP,DEPT 144,INFECT DIS LAB,DK-2650 HVIDOVRE,DENMARK
[2] GOTHENBURG UNIV,DEPT CLIN VIROL,S-41346 GOTHENBURG,SWEDEN
来源:
关键词:
D O I:
10.1006/viro.1996.0173
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
A conserved N-glycan present within the V3 loop of gp120 modulates the sensitivity to neutralization by antibodies directed to the Vs loop. A glycan-deficient mutant of HIVLAI, designated HIVA308, displayed a 100-fold increase in sensitivity to neutralization by anti-V3 MAb NEA-9205 compared to wild-type HIVLAI. This difference in sensitivity was not caused by an alteration of the antibody binding site itself, as NEA-9205 had equal affinity for both wild-type and mutant monomeric gp120, In contrast, virion-associated wild-type gp120 was immunoprecipitated less efficiently with NEA-9205 than virion-associated mutant gp120. This difference was completely abrogated, if immunoprecipitation were carried out in the presence of detergent. Furthermore, treatment of virion preparations with detergent exposed the C-terminal D7324 epitope, which is inaccessible on virion-associated gp120 but readily accessible on monomeric, soluble gp120. Finally, both wild-type and mutant monomeric, soluble gp120 were precipitated equally efficiently by NEA-9205 in the absence of detergent. Thus, the NEA-9205 epitope was readily accessible on monomeric gp120 regardless of the presence of the N-306-glycan, and inaccessibility of the NEA-9205 epitope imparted by the N-306-glycan was observed only on the intact envelope oligomer. (C) 1996 Academic Press, Inc.
引用
收藏
页码:134 / 140
页数:7
相关论文
共 34 条
- [1] RESISTANCE OF PRIMARY ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TO SOLUBLE CD4 IS INDEPENDENT OF CD4-RGP120 BINDING-AFFINITY[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) : 7056 - 7060ASHKENAZI, A论文数: 0 引用数: 0 h-index: 0机构: GENENTECH INC,DEPT RECOVERY PROC RES,SAN FRANCISCO,CA 94080SMITH, DH论文数: 0 引用数: 0 h-index: 0机构: GENENTECH INC,DEPT RECOVERY PROC RES,SAN FRANCISCO,CA 94080MARSTERS, SA论文数: 0 引用数: 0 h-index: 0机构: GENENTECH INC,DEPT RECOVERY PROC RES,SAN FRANCISCO,CA 94080RIDDLE, L论文数: 0 引用数: 0 h-index: 0机构: GENENTECH INC,DEPT RECOVERY PROC RES,SAN FRANCISCO,CA 94080GREGORY, TJ论文数: 0 引用数: 0 h-index: 0机构: GENENTECH INC,DEPT RECOVERY PROC RES,SAN FRANCISCO,CA 94080HO, DD论文数: 0 引用数: 0 h-index: 0机构: GENENTECH INC,DEPT RECOVERY PROC RES,SAN FRANCISCO,CA 94080CAPON, DJ论文数: 0 引用数: 0 h-index: 0机构: GENENTECH INC,DEPT RECOVERY PROC RES,SAN FRANCISCO,CA 94080
- [2] AN N-GLYCAN WITHIN THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP120 V3 LOOP AFFECTS VIRUS NEUTRALIZATION[J]. VIROLOGY, 1994, 199 (02) : 431 - 438BACK, NKT论文数: 0 引用数: 0 h-index: 0机构: UNIV AMSTERDAM,ACAD MED CTR,DEPT VIROL,1105 AZ AMSTERDAM,NETHERLANDSSMIT, L论文数: 0 引用数: 0 h-index: 0机构: UNIV AMSTERDAM,ACAD MED CTR,DEPT VIROL,1105 AZ AMSTERDAM,NETHERLANDSDEJONG, JJ论文数: 0 引用数: 0 h-index: 0机构: UNIV AMSTERDAM,ACAD MED CTR,DEPT VIROL,1105 AZ AMSTERDAM,NETHERLANDSKEULEN, W论文数: 0 引用数: 0 h-index: 0机构: UNIV AMSTERDAM,ACAD MED CTR,DEPT VIROL,1105 AZ AMSTERDAM,NETHERLANDSSCHUTTEN, M论文数: 0 引用数: 0 h-index: 0机构: UNIV AMSTERDAM,ACAD MED CTR,DEPT VIROL,1105 AZ AMSTERDAM,NETHERLANDSGOUDSMIT, J论文数: 0 引用数: 0 h-index: 0机构: UNIV AMSTERDAM,ACAD MED CTR,DEPT VIROL,1105 AZ AMSTERDAM,NETHERLANDSTERSMETTE, M论文数: 0 引用数: 0 h-index: 0机构: UNIV AMSTERDAM,ACAD MED CTR,DEPT VIROL,1105 AZ AMSTERDAM,NETHERLANDS
- [3] CRYPTIC NATURE OF ENVELOPE V3 REGION EPITOPES PROTECTS PRIMARY MONOCYTOTROPIC HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 FROM ANTIBODY NEUTRALIZATION[J]. JOURNAL OF VIROLOGY, 1994, 68 (09) : 6006 - 6013BOUHABIB, DC论文数: 0 引用数: 0 h-index: 0机构: NCI,CTR BIOL EVALUAT & RES,DIV HEMATOL PROD,BETHESDA,MD 20892RODERIQUEZ, G论文数: 0 引用数: 0 h-index: 0机构: NCI,CTR BIOL EVALUAT & RES,DIV HEMATOL PROD,BETHESDA,MD 20892ORAVECZ, T论文数: 0 引用数: 0 h-index: 0机构: NCI,CTR BIOL EVALUAT & RES,DIV HEMATOL PROD,BETHESDA,MD 20892BERMAN, PW论文数: 0 引用数: 0 h-index: 0机构: NCI,CTR BIOL EVALUAT & RES,DIV HEMATOL PROD,BETHESDA,MD 20892LUSSO, P论文数: 0 引用数: 0 h-index: 0机构: NCI,CTR BIOL EVALUAT & RES,DIV HEMATOL PROD,BETHESDA,MD 20892NORCROSS, MA论文数: 0 引用数: 0 h-index: 0机构: NCI,CTR BIOL EVALUAT & RES,DIV HEMATOL PROD,BETHESDA,MD 20892
- [4] ANTIGENIC IMPLICATIONS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE QUATERNARY STRUCTURE - OLIGOMER-SPECIFIC AND OLIGOMER-SENSITIVE MONOCLONAL-ANTIBODIES[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (24) : 11699 - 11703BRODER, CC论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104 UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104EARL, PL论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104 UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104LONG, D论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104 UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104ABEDON, ST论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104 UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104MOSS, B论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104 UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104DOMS, RW论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104 UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104
- [5] HIGH-CONCENTRATIONS OF RECOMBINANT SOLUBLE CD4 ARE REQUIRED TO NEUTRALIZE PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) : 6574 - 6578DAAR, ES论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,8700 BEVERLY BLVD,LOS ANGELES,CA 90048 UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,8700 BEVERLY BLVD,LOS ANGELES,CA 90048LI, XL论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,8700 BEVERLY BLVD,LOS ANGELES,CA 90048 UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,8700 BEVERLY BLVD,LOS ANGELES,CA 90048MOUDGIL, T论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,8700 BEVERLY BLVD,LOS ANGELES,CA 90048 UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,8700 BEVERLY BLVD,LOS ANGELES,CA 90048HO, DD论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,8700 BEVERLY BLVD,LOS ANGELES,CA 90048 UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,8700 BEVERLY BLVD,LOS ANGELES,CA 90048
- [6] HIV-1 NEUTRALIZING MONOCLONAL-ANTIBODIES INDUCED BY A SYNTHETIC PEPTIDE[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (09) : 1115 - 1123DURDA, PJ论文数: 0 引用数: 0 h-index: 0机构: INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDBACHELER, L论文数: 0 引用数: 0 h-index: 0机构: INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDCLAPHAM, P论文数: 0 引用数: 0 h-index: 0机构: INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDJENOSKI, AM论文数: 0 引用数: 0 h-index: 0机构: INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDLEECE, B论文数: 0 引用数: 0 h-index: 0机构: INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDMATTHEWS, TJ论文数: 0 引用数: 0 h-index: 0机构: INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDMCKNIGHT, A论文数: 0 引用数: 0 h-index: 0机构: INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDPOMERANTZ, R论文数: 0 引用数: 0 h-index: 0机构: INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDRAYNER, M论文数: 0 引用数: 0 h-index: 0机构: INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLANDWEINHOLD, KJ论文数: 0 引用数: 0 h-index: 0机构: INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND
- [7] FOLDING, INTERACTION WITH GRP78-BIP, ASSEMBLY, AND TRANSPORT OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE PROTEIN[J]. JOURNAL OF VIROLOGY, 1991, 65 (04) : 2047 - 2055EARL, PL论文数: 0 引用数: 0 h-index: 0机构: NIAID,VIRAL DIS LAB,BETHESDA,MD 20892MOSS, B论文数: 0 引用数: 0 h-index: 0机构: NIAID,VIRAL DIS LAB,BETHESDA,MD 20892DOMS, RW论文数: 0 引用数: 0 h-index: 0机构: NIAID,VIRAL DIS LAB,BETHESDA,MD 20892
- [8] NATIVE OLIGOMERIC HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN ELICITS DIVERSE MONOCLONAL-ANTIBODY REACTIVITIES[J]. JOURNAL OF VIROLOGY, 1994, 68 (05) : 3015 - 3026EARL, PL论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USABRODER, CC论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USALONG, D论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USALEE, SA论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USAPETERSON, J论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USACHAKRABARTI, S论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USADOMS, RW论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USAMOSS, B论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA
- [9] OLIGOMERIC STRUCTURE OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) : 648 - 652EARL, PL论文数: 0 引用数: 0 h-index: 0机构: NCI,PATHOL LAB,BETHESDA,MD 20892 NCI,PATHOL LAB,BETHESDA,MD 20892DOMS, RW论文数: 0 引用数: 0 h-index: 0机构: NCI,PATHOL LAB,BETHESDA,MD 20892 NCI,PATHOL LAB,BETHESDA,MD 20892MOSS, B论文数: 0 引用数: 0 h-index: 0机构: NCI,PATHOL LAB,BETHESDA,MD 20892 NCI,PATHOL LAB,BETHESDA,MD 20892
- [10] IDENTIFICATION OF AN N-LINKED GLYCAN IN THE V1-LOOP OF HIV-1 GP120 INFLUENCING NEUTRALIZATION BY ANTI-V3 ANTIBODIES AND SOLUBLE CD4[J]. ARCHIVES OF VIROLOGY, 1994, 139 (3-4) : 253 - 261GRAM, GJ论文数: 0 引用数: 0 h-index: 0机构: GOTHENBURG UNIV,DEPT CLIN VIROL,S-41346 GOTHENBURG,SWEDENHEMMING, A论文数: 0 引用数: 0 h-index: 0机构: GOTHENBURG UNIV,DEPT CLIN VIROL,S-41346 GOTHENBURG,SWEDENBOLMSTEDT, A论文数: 0 引用数: 0 h-index: 0机构: GOTHENBURG UNIV,DEPT CLIN VIROL,S-41346 GOTHENBURG,SWEDENJANSSON, B论文数: 0 引用数: 0 h-index: 0机构: GOTHENBURG UNIV,DEPT CLIN VIROL,S-41346 GOTHENBURG,SWEDENOLOFSSON, S论文数: 0 引用数: 0 h-index: 0机构: GOTHENBURG UNIV,DEPT CLIN VIROL,S-41346 GOTHENBURG,SWEDENAKERBLOM, L论文数: 0 引用数: 0 h-index: 0机构: GOTHENBURG UNIV,DEPT CLIN VIROL,S-41346 GOTHENBURG,SWEDENNIELSEN, JO论文数: 0 引用数: 0 h-index: 0机构: GOTHENBURG UNIV,DEPT CLIN VIROL,S-41346 GOTHENBURG,SWEDENHANSEN, JES论文数: 0 引用数: 0 h-index: 0机构: GOTHENBURG UNIV,DEPT CLIN VIROL,S-41346 GOTHENBURG,SWEDEN