Drug Resistance in Glioblastoma: A Mini Review

被引：236

作者：

Haar, Catherine P. ^{[1
,2
]}

Hebbar, Preetha ^{[1
,2
]}

Wallace, Gerald C. ^{[1
,2
]}

Das, Arabinda ^{[1
,2
]}

Vandergrift, William A., III ^{[1
,2
]}

Smith, Joshua A. ^{[1
,2
]}

Giglio, Pierre ^{[1
,2
]}

Patel, Sunil J. ^{[1
,2
]}

Ray, Swapan K. ^{[3
]}

Banik, Naren L. ^{[1
,2
]}

机构：

[1] Med Univ S Carolina, Dept Neurosci, Div Neurol, Charleston, SC 29425 USA

[2] Med Univ S Carolina, Dept Neurosci, Div Neurosurg, Charleston, SC 29425 USA

[3] Univ S Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29209 USA

来源：

NEUROCHEMICAL RESEARCH | 2012年 / 37卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Glioblastoma multiforme; Multidrug resistance; Glioblastoma stem cells; p-Glycoprotein; Hypoxia-inducible factors; miRNAs; Alternative therapies; RESTRICTED KETOGENIC DIET; MULTIDRUG-RESISTANCE; MOLECULAR-MECHANISMS; P-GLYCOPROTEIN; PROMOTER METHYLATION; INDUCED-APOPTOSIS; U87MG CELLS; STEM-CELLS; PHASE-II; CANCER;

D O I：

10.1007/s11064-011-0701-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Glioblastoma multiforme (GBM) is recognized as the most common and lethal form of central nervous system cancer. Currently used surgical techniques, chemotherapeutic agents, and radiotherapy strategies have done very little in extending the life expectancies of patients diagnosed with GBM. The difficulty in treating this malignant disease lies both in its inherent complexity and numerous mechanisms of drug resistance. In this review, we summarize several of the primary mechanisms of drug resistance. We reviewed available published literature in the English language regarding drug resistance in glioblastoma. The reasons for drug resistance in glioblastoma include drug efflux, hypoxic areas of tumor cells, cancer stem cells, DNA damage repair, and miRNAs. Many potential therapies target these mechanisms, including a series of investigated alternative and plant-derived agents. Future research and clinical trials in glioblastoma patients should pursue combination of therapies to help combat drug resistance. The emerging new data on the potential of plant-derived therapeutics should also be closely considered and further investigated.

引用

页码：1192 / 1200

页数：9

共 67 条

[1]

Emerging Significance of Flavonoids as P-Glycoprotein Inhibitors in Cancer Chemotherapy [J].

Bansal, Tripta ;

Jaggi, Manu ;

Khar, Roop K. ;

Talegaonkar, Sushama .

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2009, 12 (01) :46-78

[2]

Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor [J].

Bao, Shideng ;

Wu, Qiulian ;

Sathornsumetee, Sith ;

Hao, Yueling ;

Li, Zhizhong ;

Hjelmeland, Anita B. ;

Shi, Oing ;

McLendon, Roger E. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

CANCER RESEARCH, 2006, 66 (16) :7843-7848

[3]

How Avastin potentiates chemotherapeutic drugs - Action and reaction in antiangiogenic therapy [J].

Blagosklonny, MV .

CANCER BIOLOGY & THERAPY, 2005, 4 (12) :1307-1310

[4]

Tumor microenvironment and the response to anticancer therapy [J].

Brown, JM .

CANCER BIOLOGY & THERAPY, 2002, 1 (05) :453-458

[5]

Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment [J].

Cahill, Daniel P. ;

Levine, Kymberly K. ;

Betensky, Rebecca A. ;

Codd, Patrick J. ;

Romany, Candice A. ;

Reavie, Linsey B. ;

Batchelor, Tracy T. ;

Futreal, P. Andrew ;

Stratton, Michael R. ;

Curry, William T. ;

Iafrate, A. John ;

Louis, David N. .

CLINICAL CANCER RESEARCH, 2007, 13 (07) :2038-2045

[6]

Molecular mechanisms and clinical applications of angiogenesis [J].

Carmeliet, Peter ;

Jain, Rakesh K. .

NATURE, 2011, 473 (7347) :298-307

[7]

Unleashing Chk1 in cancer therapy [J].

Carrassa, Laura ;

Damia, Giovanna .

CELL CYCLE, 2011, 10 (13) :2121-2128

[8]

Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models [J].

Chen, Thomas C. ;

Wang, Weijun ;

Golden, Encouse B. ;

Thomas, Simmy ;

Sivakumar, Walavan ;

Hofman, Florence M. ;

Louie, Stan G. ;

Schoenthal, Axel H. .

CANCER LETTERS, 2011, 302 (02) :100-108

[9]

L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1 [J].

Cheng, Lin ;

Wu, Qiulian ;

Huang, Zhi ;

Guryanova, Olga A. ;

Huang, Qian ;

Shou, Weinian ;

Rich, Jeremy N. ;

Bao, Shideng .

EMBO JOURNAL, 2011, 30 (05) :800-813

[10]

Comerford KM, 2002, CANCER RES, V62, P3387

← 1 2 3 4 5 6 7 →