Design of scytalone dehydratase inhibitors as rice blast fungicides: (N-phenoxypropyl)-careoxamides

被引：22

作者：

Jordan, DB

Lessen, TA

Wawrzak, Z

Bisaha, JJ

Gehret, TC

Hansen, SL

Schwartz, RS

Basarab, GS ^{[1
]}

机构：

[1] Dupont Co, Stine Haskell Res Ctr, Newark, DE 19714 USA

[2] Dupont Co, Expt Stn, Wilmington, DE 19880 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(99)00246-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Insights gained from a crystal structure of scytalone dehydratase led to the design of carboxamide inhibitors with a phenoxypropyl group substituted on the nitrogen atom. Potent enzyme inhibitors were synthesized around this motif, the best of which provided excellent control of rice blast disease in greenhouse assays and outdoor field trials. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1607 / 1612

页数：6

共 17 条

[1]

BASARAB GS, 1998, Patent No. 9833765

[2]

BASARAB GS, 1999, IN PRESS BIOCHEMISTR, V38

[3] BIOSYNTHESIS AND FUNCTIONS OF FUNGAL MELANINS [J].